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Past Research
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NK-1 receptors and developing pain pathways
The aims of this project are to (i) characterize postnatal expression of NK-1 receptors in the dorsal horn of young and adult rats. (ii) investigate whether lamina I NK-1 expressing neurons and the parabrachial nuclei can be activated by noxious stimuli in the postnatal rat
The role of genetics and environment in pain
Assessing the role of genetic and environmental factors in the sensation of pain using a human psychophysical pain study on a large population of monozygotic and dizygotic twins. This is combined with genetic analysis and functional imaging to assess the inheritabilit
Data mining to reveal potentially novel genes and biological processes involved in the pain response
DNA microarrays are a new and promising biotechnology which allow the monitoring of expression levels in cells for thousands of genes simultaneously. To characterise the molecular events underlying neuropathy and its chronic pain, the London Pain Consortium is using microarrays
Using RNA interference to study the role of potassium channels in neuropathic pain
One of the main mechanisms for the emergence of neuropathic pain is increased spontaneous activity of neuronal components in the nociceptive pathway. Ion channels are undoubtedly implicated in the determination of a neuron?s intrinsic electrical activity and therefore