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Wellcome Trust conference The Challenges of Chronic Pain

11-13 March 2015
Wellcome Trust Genome Campus, Hinxton, Cambridge, UK

Abstract deadline: 30 January 2015
Registration deadline: 16 February 2015

For more information
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Summer School, June 2009 Photos from the London Pain Consortium Summer School, held 21st-26th June 2009 in El Escorial, Madrid, Spain.

There are currently no summer schools scheduled. Please continue to check the website for updates.
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Researchersí discovery of why sunburn hurts reveals possible target for new pain relief drugs

New award funding of LPC

UK researchers tackle pain

Imperial College and the London Pain Consortium partner with a Japanese chemical company to fight chronic pain


Walking on Fire click here


London Pain Consortium: key Discoveries

Reserachers: Pain killers click here

Painstaking research - tackling chronic pain click here

The London Pain Consortium making a difference
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Nassar MA, Baker MD, Levato A, Ingram R, Mallucci G, McMahon SB, Wood JN. Nerve injury induces robust allodynia and ectopic discharges in Nav1.3 null mutant mice. Mol Pain. 2006 Oct 19;2:33

Foulkes T, Nassar MA, Lane T, Matthews EA, Baker MD, Gerke V, Okuse K, Dickenson AH, Wood JN. Deletion of annexin 2 light chain p11 in nociceptors causes deficits in somatosensory coding and pain behavior. J Neurosci. 2006 Oct 11;26(41):10499-507

Diboun I, Wernisch L, Orengo CA, Koltzenburg M. Microarray analysis after RNA amplification can detect pronounced differences in gene expression using limma. BMC Genomics. 2006 Oct 9;7:252

Rygh LJ, Suzuki R, Rahman W, Wong Y, Vonsy JL, Sandhu H, Webber M, Hunt S, Dickenson AH. Local and descending circuits regulate long-term potentiation and zif268 expression in spinal neurons. Eur J Neurosci. 2006 Aug;24(3):761-72

Zhao J, Nassar MA, Gavazzi I, Wood JN. Tamoxifen-inducible NaV1.8-CreERT2 recombinase activity in nociceptive neurons of dorsal root ganglia.
Genesis. 2006 Aug;44(8):364-71

Pezet S, McMahon SB. Neurotrophins: mediators and modulators of pain. Annu Rev Neurosci. 2006;29:507-38. Review

Slater R, Cantarella A, Gallella S, Worley A, Boyd S, Meek J, Fitzgerald M. Cortical pain responses in human infants. J Neurosci. 2006 Apr 5;26(14):3662-6

Pezet S, Krzyzanowska A, Wong LF, Grist J, Mazarakis ND, Georgievska B, McMahon SB. Reversal of neurochemical changes and pain-related behavior in a model of neuropathic pain using modified lentiviral vectors expressing GDNF. Mol Ther. 2006 Jun;13(6):1101-9. Epub 2006 Feb 28

Matthews EA, Wood JN, Dickenson AH. Nav 1.8-null mice show stimulus-dependent deficits in spinal neuronal activity. Mol Pain. 2006 Feb 14;2:5

Hathway G, Harrop E, Baccei M, Walker S, Moss A, Fitzgerald M. postnatal switch in GABAergic control of spinal cutaneous reflexes. Eur J Neurosci. 2006 Jan;23(1):112-8

Hathway GJ,Fitzgerald M. Time course and dose-dependence of nerve growth factor-induced secondary hyperalgesia in the mouse. J Pain. 2006 Jan;7(1):57-61

Zhao J, Seereeram A, Nassar MA, Levato A, Pezet S, Hathaway G, Morenilla-Palao C, Stirling C, Fitzgerald M, McMahon SB, Rios M, Wood JN; London Pain Consortium.Nociceptor-derived brain-derived neurotrophic factor regulates acute and inflammatory but not neuropathic pain.
Mol Cell Neurosci. 2006 Mar;31(3):539-48. Epub 2006 Jan 18

Dickenson AH, Bee LA, Suzuki R. Pains, gains, and midbrains. Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):17885-6. Epub 2005 Dec 5

Urch CE, Donovan-Rodriguez T, Gordon-Williams R, Bee LA, Dickenson AH. Efficacy of chronic morphine in a rat model of cancer-induced bone pain: behavior and in dorsal horn pathophysiology. J Pain. 2005 Dec;6(12):837-45

Moss A, Alvares D, Meredith-Middleton J, Robinson M, Slater R, Hunt SP, Fitzgerald M. Ephrin-A4 inhibits sensory neurite outgrowth and is regulated by neonatal skin wounding. Eur J Neurosci. 2005 Nov;22(10):2413-21

Donier E, Rugiero F, Okuse K, Wood JN. Annexin II light chain p11 promotes functional expression of acid-sensing ion channel ASIC1a. J Biol Chem. 2005 Nov 18;280(46):38666-72. Epub 2005 Sep 16

Nassar MA, Levato A, Stirling LC, Wood JN. Neuropathic pain develops normally in mice lacking both Nav1.7 and Nav1.8. Mol Pain. 2005 Aug 22;1:24

Wallace VC, Norbury TA, Rice AS. Ultrasound vocalisation by rodents does not correlate with behavioural measures of persistent pain. Eur J Pain. 2005 Aug;9(4):445-52. Epub 2004 Nov 10

Slack SE, Grist J, Mac Q, McMahon SB, Pezet S. TrkB expression and phospho-ERK activation by brain-derived neurotrophic factor in rat spinothalamic tract neurons. J Comp Neurol. 2005 Aug 15;489(1):59-68

Pezet S, Spyropoulos A, Williams RJ, McMahon SB. Activity-dependent phosphorylation of Akt/PKB in adult DRG neurons. Eur J Neurosci. 2005 Apr;21(7):1785-97

Stirling LC, Forlani G, Baker MD, Wood JN, Matthews EA, Dickenson AH, Nassar MA. Nociceptor-specific gene deletion using heterozygous NaV1.8-Cre recombinase mice. Pain. 2005 Jan;113(1-2):27-36

Jones NG, Slater R, Cadiou H, McNaughton P, McMahon SB. Acid-induced pain and its modulation in humans. J Neurosci. 2004 Dec 1;24(48):10974-9

Wood JN, Abrahamsen B, Baker MD, Boorman JD, Donier E, Drew LJ, Nassar MA, Okuse K, Seereeram A, Stirling CL, Zhao J. Ion channel activities implicated in pathological pain. Novartis Found Symp. 2004;261:32-40; discussion 40-54

Slack SE, Pezet S, McMahon SB, Thompson SW, Malcangio M. Brain-derived neurotrophic factor induces NMDA receptor subunit one phosphorylation via ERK and PKC in the rat spinal cord. Eur J Neurosci. 2004 Oct;20(7):1769-78

Nassar MA, Stirling LC, Forlani G, Baker MD, Matthews EA, Dickenson AH, Wood JN. Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain. Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12706-11. Epub 2004 Aug 16

Matthews EA, Dickenson AH. Effects of spinally administered adenine on dorsal horn neuronal responses in a rat model of inflammation. Neurosci Lett. 2004 Feb 19;356(3):211-4

Poon WY, Malik-Hall M, Wood JN,, Okuse K. Identification of binding domains in the sodium channel Na(V)1.8 intracellular N-terminal region and annexin II light chain p11. FEBS Lett. 2004 Jan 30;558(1-3):114-8

Selected Principle Investigators publications

Urch CE, Donovan-Rodriguez T, Dickenson AH. Alterations in dorsal horn neurones in a rat model of cancer-induced bone pain. Pain. 2003 Dec;106(3):347-56

Ramer MS, Bradbury EJ, Michael GJ, Lever IJ, McMahon SB. Glial cell line-derived neurotrophic factor increases calcitonin gene-related peptide immunoreactivity in sensory and motoneurons in vivo. Eur J Neurosci. 2003 Nov;18(10):2713-21

Rogelj B, Hartmann CE, Yeo CH, Hunt SP, Giese KP. Contextual fear conditioning regulates the expression of brain-specific small nucleolar RNAs in hippocampus. Eur J Neurosci. 2003 Dec;18(11):3089-96

Farquhar-Smith WP, Rice AS. A novel neuroimmune mechanism in cannabinoid-mediated attenuation of nerve growth factor-induced hyperalgesia. Anesthesiology. 2003 Dec;99(6):1391-401

Suzuki R, Green GM, Millan MJ, Dickenson AH. Electrophysiologic characterization of the antinociceptive actions of S18616, a novel and potent alpha 2-adrenoceptor agonist, after acute and persistent pain states. J Pain. 2002 Jun;3(3):234-43

Suzuki R, Hunt SP, Dickenson AH. The coding of noxious mechanical and thermal stimuli of deep dorsal horn neurones is attenuated in NK1 knockout mice.
Neuropharmacology. 2003 Dec;45(8):1093-100

Urch CE, Dickenson AH. Neuronal nitric oxide synthase modulation of dorsal horn neuronal responses in the rat: a developmental study. Dev Neurosci. 2003 Sep-Oct;25(5):301-7

Carpenter KJ, Sen S, Matthews EA, Flatters SL, Wozniak KM, Slusher BS, Dickenson AH. Effects of GCP-II inhibition on responses of dorsal horn neurones after inflammation and neuropathy: an electrophysiological study in the rat. Neuropeptides. 2003 Oct;37(5):298-306

Lever IJ, Pezet S, McMahon SB, Malcangio M. The signaling components of sensory fiber transmission involved in the activation of ERK MAP kinase in the mouse dorsal horn. Mol Cell Neurosci. 2003 Oct;24(2):259-70

Walker SM, Meredith-Middleton J, Cooke-Yarborough C, Fitzgerald M. Neonatal inflammation and primary afferent terminal plasticity in the rat dorsal horn. Pain. 2003 Sep;105(1-2):185-95

Gadd CA, Murtra P, De Felipe C, Hunt SP. Neurokinin-1 receptor-expressing neurons in the amygdala modulate morphine reward and anxiety behaviors in the mouse.
J Neurosci. 2003 Sep 10;23(23):8271-80

Flatters SJ, Fox AJ, Dickenson AH. Spinal interleukin-6 (IL-6) inhibits nociceptive transmission following neuropathy. Brain Res. 2003 Sep 12;984(1-2):54-62

Urch CE, Dickenson AH. In vivo single unit extracellular recordings from spinal cord neurones of rats. Brain Res Brain Res Protoc. 2003 Aug;12(1):26-34

Passmore GM, Selyanko AA, Mistry M, Al-Qatari M, Marsh SJ, Matthews EA, Dickenson AH, Brown TA, Burbidge SA, Main M, Brown DA. KCNQ/M currents in sensory neurons: significance for pain therapy. J Neurosci. 2003 Aug 6;23(18):7227-36

Bridges D, Rice AS, Egertova M, Elphick MR, Winter J, Michael GJ. Localisation of cannabinoid receptor 1 in rat dorsal root ganglion using in situ hybridisation and immunohistochemistry. Neuroscience. 2003;119(3):803-12

Torsney C, Fitzgerald M. Spinal dorsal horn cell receptive field size is increased in adult rats following neonatal hindpaw skin injury. J Physiol. 2003 Jul 1;550(Pt 1):255-61. Epub 2003 May 23

Baccei ML, Bardoni R, Fitzgerald M. Development of nociceptive synaptic inputs to the neonatal rat dorsal horn: glutamate release by capsaicin and menthol. J Physiol. 2003 May 15;549(Pt 1):231-42. Epub 2003 Apr 4

Rudhard Y, Kneussel M, Nassar MA, Rast GF, Annala AJ, Chen PE, Tigaret CM, Dean I, Roes J, Gibb AJ, Hunt SP, Schoepfer R.Absence of Whisker-related pattern formation in mice with NMDA receptors lacking coincidence detection properties and calcium signaling. J Neurosci. 2003 Mar 15;23(6):2323-32

Baker MD, Chandra SY, Ding Y, Waxman SG, Wood JN. GTP-induced tetrodotoxin-resistant Na+ current regulates excitability in mouse and rat small diameter sensory neurones. J Physiol. 2003 Apr 15;548(Pt 2):373-82. Epub 2003 Mar 21

Battaglia AA, Sehayek K, Grist J, McMahon SB, Gavazzi I. EphB receptors and ephrin-B ligands regulate spinal sensory connectivity and modulate pain processing. Nat Neurosci. 2003 Apr;6(4):339-40

Flatters SJ, Fox AJ, Dickenson AH. In vivo and in vitro effects of peripheral galanin on nociceptive transmission in naive and neuropathic states. Neuroscience. 2003;116(4):1005-12

Malik-Hall M, Poon WY, Baker MD, Wood JN, Okuse K. Sensory neuron proteins interact with the intracellular domains of sodium channel NaV1.8. Brain Res Mol Brain Res. 2003 Feb 20;110(2):298-304