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Chronic pain: the search for a killer

Researchers engaging with local communities

Researchers’ discovery of why sunburn hurts reveals possible target for new pain relief drugs

New award funding of LPC

UK researchers tackle pain

Imperial College and the London Pain Consortium partner with a Japanese chemical company to fight chronic pain


Walking on Fire click here


London Pain Consortium: key Discoveries

Reserachers: Pain killers click here

Painstaking research - tackling chronic pain click here

The London Pain Consortium making a difference
Summer School, June 2009 Photos from the London Pain Consortium Summer School, held 21st-26th June 2009 in El Escorial, Madrid, Spain.

There are currently no summer schools scheduled. Please continue to check the website for updates.
Wellcome Trust conference The Challenges of Chronic Pain

11-13 March 2015
Wellcome Trust Genome Campus, Hinxton, Cambridge, UK

Abstract deadline: 30 January 2015
Registration deadline: 16 February 2015

For more information
click here

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Tsang SW, Shao D, Cheah KS, Okuse K, Leung PS, Yao KM. Increased basal insulin secretion in Pdzd2-deficient mice. Mol Cell Endocrinol. 2010 Feb 5;315(1-2):263-70. Epub 2009 Nov 20.

Swanwick RS, Pristerá A, Okuse K. The trafficking of Na(V)1.8. Neurosci Lett. 2010 Dec 10;486(2):78-83. Epub 2010 Sep 15

Kremeyer B, Lopera F, Cox JJ, Momin A, Rugiero F, Marsh S, Woods CG, Jones NG, Paterson KJ, Fricker FR, Villegas A, Acosta N, Pineda-Trujillo NG, Ramírez JD, Zea J, Burley MW, Bedoya G, Bennett DL, Wood JN, Ruiz-Linares A. A gain-of-function mutation in TRPA1 causes familial episodic pain syndrome. Neuron. 2010 Jun 10;66(5):671-80

Calvo M, Zhu N, Tsantoulas C, Ma Z, Grist J, Loeb JA, Bennett DL. Neuregulin-ErbB signaling promotes microglial proliferation and chemotaxis contributing to microgliosis and pain after peripheral nerve injury. J Neurosci. 2010 Apr 14;30(15):5437-50

Perkins JR, Diboun I, Dessailly BH, Lees JG, Orengo C. Transient protein-protein interactions: structural, functional, and network properties. Structure. 2010 Oct 13;18(10):1233-43

Zhao J, Lee MC, Momin A, Cendan CM, Shepherd ST, Baker MD, Asante C, Bee L, Bethry A, Perkins JR, Nassar MA, Abrahamsen B, Dickenson A, Cobb BS, Merkenschlager M, Wood JN. Small RNAs control sodium channel expression, nociceptor excitability, and pain thresholds. J Neurosci. 2010 Aug 11;30(32):10860-71

Legg ED, Novejarque A, Rice AS. The Three Ages of Rat: the influence of rodent age on affective and cognitive outcome measures in peripheral neuropathic pain. Pain. 2009 Jul;144(1-2):12-3. Epub 2009 May 22

Bee LA, Dickenson AH. Effects of lacosamide, a novel sodium channel modulator, on dorsal horn neuronal responses in a rat model of neuropathy. Neuropharmacology. 2009 Sep;57(4):472-9. Epub 2009 Jun 30

Shao D, Okuse K, Djamgoz MB, Protein-protein interactions involving voltage-gated sodium channels: Post-translational regulation, intracellular trafficking and functional expression. Int J Biochem Cell Biol. 2009 Jul;41(7):1471-81. EPub 2009 Feb 2

Shao D, Baker MD, Abrahamsen B, Rugiero F, Malik-Hall M, Poon WY, Cheah KS, Yao KM, Wood JN, Okuse K. A multi PDZ-domain protein Pdzd2 contributes to functional expression of senosry neuron-specific sodium channel Na(V)1.8. Mol Cell Neurosci. 2009Nov;42(3):219-25. Epub 2009 Jul 14

Hathway GJ, Koch S, Low L, Fitzgerald M. The changing balance of brainstem-spinal cord modulation of pain processing over the first weeks of rat postnatal life. J. Physiol. 2009 Jun 15;587(Pt 12):2927-35. Epub 2009 Apr 29

Bishop T, Ballard A, Holmes H, Young AR, McMahon SB. Ultraviolet-B induced inflammation of human skin: Characterisation and comparsion with traditional models of hyperlagesia. European Journal of Pain. 2009 May;13(5):524-32. Epub Aug 6 2008

Staniland AA, McMahon SB. Mice lacking acid-sensing ion channels (ASIC) 1 or 2, but not ASIC3, show increased pain behaviour in the formalin test. European Journal of Pain. 2009 Jul;13(6):554-63. Epub Sept 16 2008

Maratou K, Wallace VC, Hasnie FS, Okuse KO, Hosseini R, Jina N, Blackbeard J, Pheby T, Orengo C, Dickenson AH, McMahon SB, Rice AS. Comparison of dorsal root ganglion gene expression in rat models of traumatic and HIV-associated neuropathic pain. European Journal of Pain. 2009 Apr;13(4):387-98. Epub Jul 5 2008

Marchand F, Tsantoulas C, Singh D, Grist J, Clark AK, Bradbury EJ, McMahon SB. Effects of Etanercept and Minocycline in a rat model of spinal cord injury. European Journal of Pain. 2009 Aug;13)7):673-81. Epub 10 Oct 2008

Fricker FR, Zhu N, Tsantoulas C, Abrahamsen B, Nassar MA, Thakur M, Garratt AN, Birchmeier C, McMahon SB, Wood JN, Bennett DL. Sensory axon-derived neuregulin-1 is required for axoglial signaling and normal sensory function but not for long-term axon maintenance.Journal of Neuroscience. 2009 Jun 17;29(24):7667-78

Lever IJ, Robinson M, Cibelli M, Paule C, Santha P, Yee L, Hunt SP, Cravatt BF, Elphick MR, Nagy I, Rice ASC. Localisation of the endocannabinoid-degrading enzyme fatty acid amide hydrolase in rat dorsal root ganglion cells and it's regulation following peripheral nerve injury. Journal of Neuroscience. 2009;29:3766-3780

Nguyen D, Deng P, Matthews EA, Kim DS, Feng G, Dickenson AH, Xu ZC, Luo ZD. Enhanced pre-synaptic glutamate release in deep-dorsal horn contributes to calcium channel alpha-2-delta-1 protien-mediated spinal sensitization and behavioural hypersensitivity. Molecular Pain. 2009 Feb 12;5:6

Huang HL., Cendan CM., Roza C., Okuse K., Cramer R., Timms JF., Wood JN. Proteomic profiling of neurones reveals alterations in protein composition and local protein syntheses in hyper-excitable nerves. Molecular Pain. 2008 Aug 12;4:33

Moss A., Ingram R., Koch S., Theodorou A., Low L., Baccei M., Hathway GJ., Costigan M., Salton SR., Fitzgerald M. Origins, actions and dynamic expression patterns of the neuropeptride VGF in rat peripheral and central senoary neuornes following peripheral nerve injury. Molecular Pain. 2008 Dec 10;4:62

Vonsy JL., Ghandehari J., Dickenson AH. Differential analgesic effects of morphine and gabapentin on behavioural measures of pain and disability in a model of ostesarthritis. European Journal of Pain. 2008 Oct 25 (epub)

Rice ASC., Lever I., Zarnegar R. Cannabinoids and Pain. Sixth IASP Research Symposium, ICECAP 2006 - Systematic Reviews and Meta Analyses in Pain: Lessons from the past leading to pathways for the future. IASP Press Seattle. Eds McQuay HJ. & Moore RA. 2008. Ch 19, 233-246

Wallace VCJ., Rice ASC. 2008. Applied Physiology: Neuropathic Pain. In Textbook of Clinical Pain Management, 2nd edition. Hodder

Wallace VCJ., Segerdahl AR, Blackbeard J., Pheby T., Rice ASC. Anxiety-like behaviour is attenuated by gabapentin, morphine and diazepam in a rodent model of HIV anti-retroviral associated neuropathic pain. Neuroscience Letters. 2008;448:153-156

Abrahamsen B., Zhao J., Asante C., Cendan C., Marsh S., Martinez-Barbera J., Nassar M., Dickenson AH, Wood JN. The cell and molecular basis of mechanical, cold and inflammatory pain. Science. 2008 321(5889):702-5

Ostman JA, Nasser MA, Wood JN, Baker MD. GTP up-regulated persistent Na+ and enhanced nociceptor excitability require NaV1.9. Journal of Physiology. 2008 15;586(4):1077-87

Onkal R., Mattis JH., Fraser SP., Diss JK., Shao D., Okuse K., Djamgoz MB. Alternative splicing of Nav1.5:an electrophysiological comparsion of 'neonatal' and 'adult' isoforms and critical involvement of a lysine residue. Journal of Cell Pysiology. 2008 Sep;216(3):716-26

Bee LA., Dickenson AH. Descending facilitation from the brainstem determines behavioural and neuronal hypersensitivity following nerve injury and efficacy of pregabalin. Pain. 2008 Sept 20 (epub)

Pezet S., Marchand F., D'Mello R., Grist J., Clark AK., Malcangio M., Dickenson AH., Williams RJ., McMahon SB. Phosphatidylinositol 3-kinase is a key mediator of central sensitization in painful inflammatory conditions. Journal of Neuroscience. 2008 Apr 16;28(16)4261-70

Cafferty WB., Bradbury EJ., Lidierth M., Jones M., Duffy PJ., Pezet S., McMahon SB. Chondroitinase ABC-mediated plasticity of spinal sensory function. Journal of Neuroscience. 2008 Nov 12;28(46):11998-2009

D'Mello R., Dickenson AH. Spinal cord mechanisms of pain. British Journal of Anaesthetics. 2008 Jul;101(1):8-16

Rahman W., D'Mello R., Dickenson AH. Peripheral nerve injury-induced changes in spinal alpha(2)adrenoceptor-mediated modulation of mechanically evoked dorsal horn neuronal responses. Journal of Pain. 2008Apr;9(4):350-9

Norbury TA., MacGregor AJ., Urwin J., Spector TD., McMahon SB. Heritability of responses to painful stimuli in women: a classical twin study. Brain. 2007 Nov;130(Pt 11):3041-9. Epub 2007 Oct 11

Gordon-Williams RM. & Dickenson AH. Central neuronal mechanisms in cancer-induced bone pain. Current Opinion Support Pallative Care. 2007 Apr;1(1):6-10 review

Okuse K. Pain signalling pathways:from cytokines to ion channels. International Journal of Biochemistry Cell Biology. 2007;39(3):490-6. Epub 2006 Nov review

Slater R., Fitzgerald M., Meek J. Can cortical responses following noxious stimulation inform us about pain processing in neonates?. Semin Perinatol. 2007 Oct 31(5):298-302

Wallace VC, Blackbeard J, Sergerdahl AR, Hasnie F, Pheby T, McMahon SB, Rice AS. Characterization of rodent models of HIV-gp120 and anti-retroviral-associated neuropathic pain. Brain. 2007 Oct;130(Pt 10): 2688-702

Geranton SM., Morenilla C., Hunt SP. A role for transcriptional repressor methyl-CpG-binding protein 2 and plasticity-related gene serum- and glucocorticoid-inducible kinases 1 in the induction of inflammatory pain states. Journal of Neuroscience. 2007 Jun 6;27(23):6163-73

Matthews EA, Bee LA, Stephens GJ, Dickenson AH. The Cav2.3 calcium channel antagonist SNX-482 reduces dorsal horn neuronal responses in a rat model of chronic neuropathic pain. Eur J Neurosci. 2007 Jun;25(12):3561-9

Bee LA, Dickenson AH. Rostral ventromedial medulla control of spinal sensory processing in normal and pathophysiological states. Neuroscience. 2007 Jul 13;147(3):786-93. Epub 2007 Jun 14

Drew LJ, Rugiero F, Cesare P, Gale JE, Abrahamsen B, Bowden S, Heinzmann S, Robinson M, Brust A, Colless B, Lewis RJ, Wood JN. High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain. PLoS ONE. 2007 Jun 13;2(6):e515

Wallace VC, Segerdahl AR, Lambert DM, Vandevoorde S, Blackbeard J, Pheby T, Hasnie F, Rice AS. The effect of the palmitoylethanolamide analogue, palmitoylallylamide (L-29) on pain behaviour in rodent models of neuropathy. Br J Pharmacol. 2007 Aug;151(7):1117-28. Epub 2007 Jun 11

Blackbeard J, O'Dea KP, Wallace VC, Segerdahl A, Pheby T, Takata M, Field MJ, Rice AS. Quantification of the rat spinal microglial response to peripheral nerve injury as revealed by immunohistochemical image analysis and flow cytometry. J Neurosci Methods. 2007 Aug 30;164(2):207-17. Epub 2007 May 4

Hasnie FS, Wallace VC, Hefner K, Holmes A, Rice AS. Mechanical and cold hypersensitivity in nerve-injured C57BL/6J mice is not associated with fear-avoidance- and depression-related behaviour. Br J Anaesth. 2007 Jun;98(6):816-22. Epub 2007 May 3

Wallace VC, Blackbeard J, Pheby T, Segerdahl AR, Davies M, Hasnie F, Hall S, McMahon SB, Rice AS. Pharmacological, behavioural and mechanistic analysis of HIV-1 gp120 induced painful neuropathy. Pain. 2007 Dec 15;133(1-3):47-63. Epub 2007 Apr 12

Lever IJ, Pheby TM, Rice AS. Continuous infusion of the cannabinoid WIN 55,212-2 to the site of a peripheral nerve injury reduces mechanical and cold hypersensitivity. Br J Pharmacol. May;151(2):292-302. Epub 2007 Mar 20

Hasnie FS, Breuer J, Parker S, Wallace V, Blackbeard J, Lever I, Kinchington PR, Dickenson AH, Pheby T, Rice AS. Further characterization of a rat model of varicella zoster virus-associated pain: Relationship between mechanical hypersensitivity and anxiety-related behavior, and the influence of analgesic drugs. Neuroscience. 2007 Feb 23;144(4):1495-508. Epub 2006 Dec 29

Moss A, Beggs S, Vega-Avelaira D, Costigan M, Hathway GJ, Salter MW, Fitzgerald M. Spinal microglia and neuropathic pain in young rats. Pain. 2007 Apr;128(3):215-24. Epub 2006 Nov 15

Lever IJ, Rice AS. Cannabinoids and pain. Handb Exp Pharmacol. 2007 177:265-306. Review