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Chronic pain: the search for a killer

Researchers engaging with local communities

Researchers’ discovery of why sunburn hurts reveals possible target for new pain relief drugs

New award funding of LPC

UK researchers tackle pain

Imperial College and the London Pain Consortium partner with a Japanese chemical company to fight chronic pain


Walking on Fire click here


London Pain Consortium: key Discoveries

Reserachers: Pain killers click here

Painstaking research - tackling chronic pain click here

The London Pain Consortium making a difference
Summer School, June 2009 Photos from the London Pain Consortium Summer School, held 21st-26th June 2009 in El Escorial, Madrid, Spain.

There are currently no summer schools scheduled. Please continue to check the website for updates.
Wellcome Trust conference The Challenges of Chronic Pain

11-13 March 2015
Wellcome Trust Genome Campus, Hinxton, Cambridge, UK

Abstract deadline: 30 January 2015
Registration deadline: 16 February 2015

For more information
click here

Eijkelkamp N, Linley JE, Baker MD, Minett MS, , Cregg R, Werdehausen R, Rugiero F, Wood JN, . Neurological perspectives on voltage-gated sodium channels. Brain. 2012 Sep;135(pt9):2585-612 Review

Raouf R, Rugiero F, Kiesewetter H, Hatch R, Hummler E, Nassar M, Wang F, Wood JN. Sodium channels and mammalian sensory mechantransduction. Molecular Pain. 2012;8:21 Published online 2012 March 26)

Pristera A, Baker MD, Okuse K. Association between tetrodotoxin resistant channels and lipid rafts regulates sensory neuron excitability. PLoS One. 2012;7(8):e40079 Epub 2012 Aug 1. Erratum in PLoS One. 2013;8(5)

Tsantoulas C, Zhu L, Shaifta Y, Grist J, Ward JP, Raouf R, Michael GJ, McMahon SB. Sensory neuron downregulation of the Kv9.1 potassium channel subunit mediates neuropathic pain following nerve injury. J. Neuroscience. 2012 Nove 28;32(48):17502-12

Blackbeard J, Wallace VCJ, O'Dea KP, Hasnie FS, Segerdahl A, Pheby T, Field M, Takata M, Rice ASC. The correlation between pain-related behaviour and spinal microgliosis in four distinct models of peripheral neuropathy. European Journal of Pain. 2012 Nov;16(10):1357-67 Epub 2012 Mar 29

Kamerman PR, Moss PJ, Weber J, Wallace VCJ, Rice ASC, Huang W. Pathogenesis of HIV-associated senosry neuropath: evidence from in vivo and in vitro experimental models. Journal of the Peripheral Nervouse System. 2012;17:19-31

Perkins JR, Dawes JM, McMahon SB, Bennett DL, Orengo C, Kohl M. ReadqPCR and NorqPCR: R packages for the reading, quality checking and normalisation of RT-qPCR quantification cycle (Cq) data. BMC Genomics. 2012 Jul 2;13:296.

Tracey I, Dickenson A. Snapshot: Pain perception. Cell 2012 Mar16;148(6):1308-1308.e2

Quick K, Zhao J, Eijkelkamp N, Linley JE, Rugiero F, Cox JJ, Raouf R, Gringhuis M, Sexton JE, Abramowitz J, Taylor R, Forge A, Ashmore J, Kirkwood N, Kros CJ, Richardson GP, Freichel M, Flockerzi V, Birnbaumer L, Wood JN. TRPC3 and TRPC6 are essential for normal mechantransduction in subsets of sensory neurons and cochlear hair cells. Open Biol. 2012 May;2(5):120068

Passmore G, Reilly J, Thakur M, Keasberry V, Marsh SJ, Dickenson AH, Brown D. Functional significance of M-tyoe potassium channels in nociceptive cutaneous senosry endings. Frontiers in Molecular Neuroscinece doi:10.3389/fnmol.2012.00063

Goncalves L. Dickenson AH, Asymmetirc time-dependent activation of right central amygdala neurones in animals with peripheral neuropathy and pregabalin modulation. Eur J Neurosci. pp. 1–10, 2012 e pub Aug 3

Minett MS, Nassas MA, Clark AK, Passmore G, Dickenson AH, Wang F, Malcangio M, Wood JN. Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons. Nature Communication. 2012 Apr 24;3:791

Thakur M, Rahman W, Hobbs C, Dickenson AH, Bennett DLH. Charaterisation of a peripheral neuropathic component of the rat monoiodoacetate model of osteoarthritis. PLos One.7(3):e33730. Epub Mar21 2012

Ramirez JD, Barnes PRJ, Mills KR, Bennett DLH. Intermediate Charcot Marie Tooth due to a novel Trp101Stop Myelin Protien Zero Mutation associated with debilitating neuropathic pain. Pain 2012 Aug;153(8):1763-8. Epub 2012 Jun 16.

Segerdahl AR, Xie J, Paterson K, Ramirez JD, Tracey I, Bennett DL. Imaging the neural correlates of neuropathic pain and pleasurable relief associated with inherited erythromelalgia in a single subject with quantitative arterial spin labelling. Pain. Volume 153, Issue 5, May 2012, Pages 1122–1127. Feb 23 (epub)

Pristera A, Okuse K. Building excitable membranes:lipid rafts and multiple controls on trafficking of electrogenic molecules. Neuroscientist. 2012 Feb;18(1)70-81. Epub 2011 Aug 26

Denk F, McMahon SB. Chronic Pain:emerging evidence for the involvement of epigentics. Neuron. 2012 Feb9;73(3):435-44

Eijkelkamp N, Heijnen CJ, Carbajal AG, Willemen HL, Wang H, Minett MS, Wood JN, Schedlowski M, Dantzer R, Kelley KW, Kavelaars A. GRK6 acts as a critical regulator of cytokine-induced hyperalgesia by promoting PI3kinase- and inhibiting p38-signaling. Mol Med. 2012 May 9;18(1):556-64. Feb 6 (epub)